Milstein (* 8 October 1927 in Blanca, Argentina; "† 24. March 2002 in Cambridge, England) was a argentischer molecular biologist.

Milstein buildup as middle of three sons of a Jewish immigrant and a teacher in modest conditions. Its parents made nevertheless a study of chemistry at the university of Buenos Aires, which it locked after one duration of seven years 1952 with the diploma for it possible. In its time as a politically active student he became acquainted with his later Mrs. Celia, whom he married after his graduation. After a Intermezzo, while whose he worked among other things for some months in a Kibbutz in Israel, it attained a doctorate to 1957 at the medical university of the University of Buenos Aires in the subject chemistry with a topic to enzymatic kinetics of aldehyde Dehydrogenase. From 1957 to 1963 it belonged to the Instituto Nacional de in Buenos Aires, whose leader became he between 1961 and 1963. In the meantime he worked postdoktoral on the faculty for biochemistry of the University of Cambridge in England, where he itself with the characteristics of the enzyme Phosphoglucomutase busy. Thereby it became acquainted with Frederick Sanger, in whose working group it was active between 1960 and 1961. Starting from 1963 Milstein as well as Sanger belonged to the scientific staff of the again-created institute for molecular biology at the University of Cambridge. Sanger encouraged Milstein to shift its scientific emphasis on the Immunologie. 1983 schiesslich became Milstein director/conductor of the department for protein and in Cambridge.

Milstein of the structural analysis of anti-body as well as the mechanisms, which are responsible for the high diversity of these Immunglobuline, dedicated itself the largest part to its scientific career. In this connection it developed 1975 together with Georges charcoal burner the hybrid granny technology, with which by fusion the production of large quantities of monoclonal anti-bodies was made possible for a Myelomzelllinie with a B-Lymphozyten. This discovery led to an enormous expansion of the use of anti-bodies in science and medicine. it received 1984 for these work as well as Niels K. Jerne and Georges J.F. charcoal burner, the Nobelpreis in physiology or medicine. Among its numerous further honors also the Robert cook price of 1980 ranks.

Milstein died at the consequences of chronic heart weakness.

Articles in category "Cr Milstein"

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