Homocystein is an intermediate product of the Methioninstoffwechsels, which is formed with the metabolism by protein in the body. Increased values can entail a damage of the blood vessels. There is to be also a connection with dementia illnesses at the age. Normal laboratory values during the blood investigation lie between 5 and 10 For the adjustment of the Homocystein level in the blood a sufficient supply of betaine is necessary and the Vitamine B12 and (FH4).

Biochemical meaning

From Homocystein, betaine and CH3 (FH4) can be up and/or diminished by the Methionin Synthase Methionin. The Methionin Synthase needs thereby the Vitamin B12 as Coenzym.

As intermediate products of this biosynthesis way FH4 and Betainhomocystein develop, whereby Betainhomocystein is converted by the Betainhomocystein Methylase to Methionin and Dimethylglycin.

Homocystein as factor of risk

Homocystein can cause and on different ways to a increased Thromboseneigung lead a direct toxic damage of the With patients with well-known koronarer heart illness are loaded already easily increased Homocysteinspiegel with a increased risk for future cardiovascular events, while the data situation is non-uniform with completely healthy humans. With a Homocysteinspiegel of over 15 however uniformly a increased risk exists in several studies.

Although and B-Vitamine lower the Homocysteinspiegel as can be prove, they did not lead in several large studies so far to a lowering of the cardiac infarct or impact accumulation risk. For this reason the determination of the Homocysteinspiegels is usually recommended only for patients, who do not exhibit other factors of risk. A therapy is recommended predominantly at values over 15

Articles in category "Homocystein"

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