Howard Martin Temin (* 10 December 1934 in Philadelphia, Pennsylvania; "† 9 February 1994 in Madison, Wisconsin) was an US-American biologist. It was distinguished 1975 for its realizations within the field of the cancer research together with David Baltimore and Renato Dulbecco with the Nobelpreis for physiology and medicine.

Personal record

After childhood and youth in Philadelphia Temin studied biology at the California institutes OF Technology ("“Caltech"”) in Pasadena/California. There it turned the experimental Virologie and worked themselves in the laboratory of Renato Dulbecco, where it made also its doctor work over the Rous Sarkom virus (Rous sarcoma virus, RSV). The RSV became for it the model system, with which he worked also in the following years. After own stating it was affected also strongly by co-operation with Harry ruby and the contact to max of 1960 it assistant professor at the McArdle Laboratory for CAN cerium Research at the university of Wisconsin Madison. 1964 he formulated his "“pro virus hypothesis"” there, which means that certain RNA viruses (Retroviren) can there integrate themselves in the human Genom and by external influences (e.g. radiotherapy, krebserregende substances, o.a.) it is activated and to cancer to lead in such a way to be able. A condition for this was the rewriting of the viralen RNA Genoms in DNA. This hypothesis hurt a fundamental acceptance of the molecular biology, which because of their apparent "“dogma of molecular biology"” was called that the information flow runs in each case in the direction DNA - > RNA - > protein, and never turned around. Later Temin discovered the enzyme, which can manage this rewriting process of RNA in DNA parallel with David Baltimore: the Reverse Transkriptase.

For its achievements it received numerous honors, beside the Nobelpreis also Albert Lasker Award for to basic Medical Research.

Related links

Short autobiography Temins for the cause of the Nobelpreisverleihung 1975

Articles in category "Howard M. Temin"

We found here 13 articles.