It became for the first time 1986 of Murray et al. in the bioassay described. Short term interruptions of the blood supply lead thereby to adaptation mechanisms which can reduce the size of the Infarktareals due to it during a final interruption of the blood vessel over up to 75%.

The which are the basis mechanisms are not yet completely clarified. However it could be shown in the meantime that potassium channel openers make this IPC possible, during potassium channel blockers of this impossible. Diazoxid is a potassium channel opener at the heart muscle cell, which in low concentrations the mitochondrialen potassium channels opens, those in the Sarkolemm leaves however uninfluenced. Since Diazoxid protects the heart muscle cells against a Infarzierung, the influence of the potassium channels of the Mitochondrien might be responsible for this protective effect.

The fact that patients with diabetes exhibit mellitus clearly higher complication rates after cardiac infarcts, led among other things. to the assumption that sulphonyl urea - medicines, which are used for blood sugar lowering - of this IPC to disturb could. Meanwhile it could be shown that actually to Glibenclamid applies. Glimepirid however does not exert negative influence on the heart fabric.

Articles in category "Ischemic Preconditioning"

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