Paul Greengard (* 11 December 1925 in New York town center) is an US-American biochemist and Pharmakologe. In the year 2000 it kept the Nobelpreis for medicine and physiology for its discoveries common with Sweden Arvid Carlsson and the American Eric Richard Kandel concerning the signal transmission in the nervous system.

Life and work

Paul Greengard attained a doctorate 1953 as a biochemist and went 1959 to the Geigy research laboratories into Ardsley. 1968 it was appointed as a professor to the Yale University School OF Medicine destined in new Haven, on which it became active as a professor for pharmacology and psychiatry. 1983 he got a Professur to the Rockefeller University in New York, where he took over at the same time the line of the laboratory for molecular biology and cellular neuro sciences

Greengard researched particularly at the signal transmission between the nerve cells in the brain, in order to clear the concrete switching up by interzellulare signal materials. It cleared above all the transmission up at the slow synapses in such a way specified, over which fundamental functions centers of the nervous system are determined as for instance tendencies or the watchfulness. He discovered that the signal material Dopamine releases a cascade of reactions inside the nerve cell, which leads apart from the modification of different cellown proteins also to the opening of ion channels. The electrical charge of the cell is turned around by the ions penetrating thereby, whereby Aktionspotenziale are released.

The realizations over the signal transmission and the effect of signal materials are particularly for the use of medicines of importance. Above all the impact of psychopharmacologic drugs, approximately against schizophrenia, can be better understood and examined thereby.

Related links

• Biographies, Nobelpreisreden etc. of the winners 2000

Articles in category "Paul Greengard"

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